WHAT CAUSES THE KIDNEY FAILURE?

Kidney failure can occur from an acute situation or from chronic problems.

In acute renal failure, kidney function is lost rapidly and can occur from a variety of insults to the body. The list of causes is often categorized based on where the injury has occurred.

Prerenal causes (pre=before + renal=kidney) causes are due to decreased blood supply to the kidney.

   Examples of prerenal causes of kidney failure are:

   * hypovolemia (low blood volume) due to blood loss

   * dehydration from loss of body fluid (for example, vomiting, diarrhea, sweating, fever)

   * poor intake of fluids

   * medication, for example, diuretics ("water pills") may cause excessive water loss

   * abnormal blood flow to and from the kidney due to obstruction of the renal artery or vein.

   
   Renal causes of kidney failure (damage directly to the kidney itself) include:

   * Sepsis: The body's immune system is overwhelmed from infection and causes inflammation and shutdown of the             kidneys. This usually does not occur with urinary tract infections.

   * Medications: Some medications are toxic to the kidney, including nonsteroidal anti-inflammatory drugs like  ibuprofen      and naproxen. Others potentially toxic medications include antibiotics like aminoglycosides.

   * Rhabdomyolysis: This is a situation in which there is significant muscle breakdown in the body, and the damaged             muscle fibers clog the filtering system of the kidneys. This can occur because of trauma, crush  injuries, and burns.        Some medications used to treat high cholesterol can cause rhabdomyolysis.

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